One of the greatest pleasures of life is the intimate relationship with a loving partner. Sexual intercourse is the way of expressing love to each other. Flaccidity of the penis makes it difficult to enjoy the sexual relationship maximally. Pfizer pharmaceuticals, a highly competitive pharmaceutical company, has filled the gap created in the sex life of couples, in whom male partners are having erection problems, through its surprisingly effective drug Viagra, highly recommended for overcoming erectile dysfunction. Impotence dares not live in front of Viagra. Viagra, a wonder drug, develops a bridge between you and your lost sexual pleasures. Physicians strongly recommend Viagra to the patients having difficulties in erection.

The process of erection starts when the brain senses any sexual stimuli. In response to sexual stimuli, the brain orders the cells present in the walls of the vessels of the penis to manufacture Nitric Oxide. The cells in the walls of the penile vessels use Nitric Oxide synthase to form Nitric Oxide from L-arginine. L-arginine is an amino acid present in the endothelial cells. Nitric Oxide slips into the lumen of the penile vessels after its formation. In the lumen, Nitric Oxide converts guanylyl cyclase, an enzyme, from its inactivated form to its activated form. Guanylyl cyclase, after its activation, stimulates the formation of cGMP from GTP. cGMP is called the queen of erection as it leads to the dilation of the penile vessels. The dilation of penile vessels results in outflow of blood from these vessels into the spongy tissue of the penis. Filling of spongy tissue of the penis with blood culminates in erection. Viagra performs its amazing erectile action by elevating the level of cGMP, a factor necessary for erection. However in the absence of sexual stimulation, Viagra is unable to perform its erectile action.

Since, the drug not only targets PDE5 alone, other enzymes might get stimulated by the drug causing side effects. Some of these side effects are diarrhea, dizziness, cyanotic vision, hearing loss, runny nose, nasal congestion and prolonged painful erection that might last for long duration. These side effects are supposed to diminish within a few hours and occur in a very low or negligible potency. If otherwise, immediately stop Viagra administrations and consult your physician for further instructions. Do not take the medication for more than once in 24 hours time as doing so would result in increased vasodilatation and ultimately circulatory collapse due to hypotension. Nitrate containing drugs that are frequently a recommended medication for heart complications are potent vasodilators and could cause extreme hypotension when accompanied with Viagra. So, nitrate containing drugs, protease inhibitors and erythromycin antibiotic are contraindicated with Viagra. Do not consume alsohol with Viagra and always apply sufficient sexual stimulation in order to experience the drug effect maximally. Available dose forms of the drug are 25 mg, 50 mg and 100 mg tablets, to be taken one at a time half an hour before sexual interaction.

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